Describe a protein that detects the presence of calcium.

Describe a protein that detects the presence of calcium. Include in your discussion a consideration of the evolutionary constraints placed on the primary structure, how calcium is detected and how its presence is transmitted to other cellular components. What bioinformatics technique(s) might be used to predictif a newly discovered protein sequence had a similar function and structure to your chosen protein? Briefly, how might you confirm some of your predictions using experimentsand what are theadvantages/disadvantages of thedifferent experimental techniques?