Discuss Biomolecules and their importance in key biological processes.

An introduction to the topic including research that discusses what sickle cell anaemia is and how it can affect the red blood cell and their function little bit of information about DNA&RNA what they are briefly and that they can Mutate. How this drives evolution and can have a positive effect/ positive adaptations over time eg the ability to digest lactose. But can also have a negative outcome such as sickle cell anaemia which is a mutation that can be inherited. In a table include a discussion on the different types of mutations Discuss the different types of mutations (3 main types) then go on to discuss the fact that these mutations can affect the proteins that they make with examples eg. PKU. Then discuss the fact that sickle cell anaemia is one of these disorders. Include image describing the protein structure of a mutated beta haemoglobin gene with text box explaining. In the next paragraph discuss how this mutation affects the structure and function of haemoglobin (eg valine causes haemoglobin to stick) in an individual with sickle cell, begin this by also discussing what normal haemoglobin is. Following on with an image to discuss how the structure of haemoglobin is different with someone who has sickle cell anemia (beta haemoglobin). Then another image that describes The affects of the distorted mutated haemoglobin with a text box discussing how affected HBs affect the red blood cells and how this leads to sickle affect/ symptoms. Final section- discuss genetic inheritance of sickle cell anaemia. Introduce and discuss what is meant by genetic inheritance. Outline meiosis and relate it back to how this formation of gametes relates to SCA. Briefly introduce ideas of other genetic conditions such as cystic fibrosis and Huntingtons. Introducehow genetic inheritance works for SCA due to it being a recessive disorder. This needs to include two full genetic diagrams as examples. The genetic diagrams need to include all information plus a discussion of the results of the mono hybrid crosses.