Discuss acute myeloid leukemia and the potential of drug called TR-57 as a treatment.

include the following: 1- what is the acute myeloid leukemia(AML) 2- current of resistance and refractory disease 3-previous research on imipridones(look for ONC-202, ONC-212) 4- hypothesis 5- Aim1(describe aim to look at sensitivityof AML cell lines to the imipridone TR-57 6-method for aim1 (flow cytometry for cytotoxicity and cell cycle effect 7-aim 2 (determine the mechanisms of action of TR57 in AML 8- methods for aim 2(western blot) 9- expected outcome 10- time line please include figures and tables.