Explain how production of lactate from pyruvate can promote glycolysis in the muscle cells.

Term Assignment each answer should not be more than 10 lines. Assignment: questions are below: Question 1. (Each answer should not exceed 10 lines) i. Explain how production of lactate from pyruvate can promote glycolysis in the muscle cells. ii. Explain why glycogenolysis in muscle cells do not generate free glucose for other body cells through blood circulation. iii. Illustrate the mechanistic role of glucose-6-phosphate dehydrogenase in prevention of haemolysis (You can sketch and comment). Read the clinical presentation and answer question 2 A 10-year old boy was found very weak and pale. Laboratory investigation revealed that the boy has malaria infection and very low haemoglobin. The boy was transfused and treated with antimalarial agents. The boy responded well to treatment until the fourth month and the boy’s condition begun to degenerate. The Physician requested for G6PDH deficiency test and the report was positive. Questions i. What accounted for the child’s condition before admission? ii. Explain why the boy recovered after the transfusion? iii. What could be the underlying cause of the reoccurrence of the episode after 4 months? iv. If both parents of the boy are asymptomatic of the G6PDH deficiency, explain why the boy showed symptoms. v. Suggest management plan for the child.