Hanahan and Weinberg included, “Deregulating cellular energetics,” as an emerging hallmark of cancer in their 2011 paper. Explain why this has been elevated to be a hallmark of cancer and how this could be targeted for cancer therapy?

1. Hanahan and Weinberg included, “Deregulating cellular energetics,” as an emerging hallmark of cancer in their 2011 paper. Explain why this has been elevated to be a hallmark of cancer and how this could be targeted for cancer therapy? 2. We reviewed the PI3K/Akt/mTOR pathway in cancer. Like other intracellular signaling pathways, this is a complex network of proteins and downstream signaling influences a wide variety of cellular outcomes. Describe the role of this pathway in cancer. In your answer, include how this pathway is regulated, at least two distinct parts of the pathway where targeted therapies have been developed, and how this is different from other examples we have seen such as targeting Bcr-Abl or B-Raf. These 2 questions are required to be answered with 500 words each. Ideally I would like to have 6 references between the two questions. The sources used can be of the writer’s choice. They have to be scientific research papers and apply to the questions at hand.